abstract：:SARS-CoV-2 is the most recent coronavirus which crossed the species barrier in 2019 and provoked a still ongoing and dangerous pandemic known as coronavirus disease 2019 (COVID-19). The SARS-CoV-2 infection has triggered an impressive amount of clinical and experimental studies to identify an effective and safe therap...

journal_title：Frontiers in pharmacology

authors： Iacob S,Iacob DG

更新日期：2020-08-26 00:00:00

abstract：Background:MicroRNAs are known to regulate carcinogenesis of osteosarcoma. Although, miR-16-5p is known to exert inhibitory effects on several forms of cancers, its effects on the growth and invasion of osteosarcoma have not been studied. Methods:We collected human osteosarcoma specimens and adjacent tissues to detect...

journal_title：Frontiers in pharmacology

authors： Gu Z,Li Z,Xu R,Zhu X,Hu R,Xue Y,Xu W

更新日期：2020-08-26 00:00:00

abstract：:Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

journal_title：Frontiers in pharmacology

authors： Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

更新日期：2020-08-21 00:00:00

abstract：:Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the interactive role o...

journal_title：Frontiers in pharmacology

authors： Maique J,Flores B,Shi M,Shepard S,Zhou Z,Yan S,Moe OW,Hu MC

更新日期：2020-08-20 00:00:00

abstract：Objective:Current prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV season. Here we present proof-of-concept data using nebulized palivizu...

journal_title：Frontiers in pharmacology

authors： Rajapaksa AE,Do LAH,Suryawijaya Ong D,Sourial M,Veysey D,Beare R,Hughes W,Yang W,Bischof RJ,McDonnell A,Eu P,Yeo LY,Licciardi PV,Mulholland EK

更新日期：2020-08-19 00:00:00

abstract：:6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), is the main bioactive compound present in Wasabia japonica rhizome. Several scientific studies have shown that 6-MITC possesses interesting antimicrobial, anti-inflammatory, antiplatelet and antioxidant properties which therefore suggested us it could have an interesti...

journal_title：Frontiers in pharmacology

authors： Cocchi V,Hrelia P,Lenzi M

更新日期：2020-08-18 00:00:00

abstract：:In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania d...

journal_title：Frontiers in pharmacology

authors： Mahmoud AB,Danton O,Kaiser M,Khalid S,Hamburger M,Mäser P

更新日期：2020-08-14 00:00:00

abstract：:Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin remodeling, histone post-translational modifications, and non-coding RNAs. Emergin...

journal_title：Frontiers in pharmacology

authors： Akone SH,Ntie-Kang F,Stuhldreier F,Ewonkem MB,Noah AM,Mouelle SEM,Müller R

更新日期：2020-08-13 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:There is an urgent unmet need to develop new therapeutics for lung squamous cell carcinoma (LSCC) as the current gold standard treatment regimens are dominated by chemotherapy. In this study, we observed the treatment effects of the natural compound tambulin on LSCC and explored its mechanism of action. LSCC cell line...

journal_title：Frontiers in pharmacology

authors： Wang W,Liu Y,Zhao L

更新日期：2020-08-12 00:00:00

abstract：:Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition the binary actin ADP-...

journal_title：Frontiers in pharmacology

authors： Korbmacher M,Fischer S,Landenberger M,Papatheodorou P,Aktories K,Barth H

更新日期：2020-08-12 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a frequently occurring type of nontraumatic osteonecrosis. A failure of the timely treatment can eventually result in the collapse of the subchondral bone structure. Luteolin (Lut), a compound extracted from Rhizoma Drynariae, is reported to possess ...

journal_title：Frontiers in pharmacology

authors： Yan Z,Zhan J,Qi W,Lin J,Huang Y,Xue X,Pan X

更新日期：2020-08-12 00:00:00

abstract：Background:Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with nondiabetic men. Corpus cavernosum vascular dysfunction plays a pivotal role in the occurrence of diabetes mellitus ED (DMED). The aim of this study was to investigate the prote...

journal_title：Frontiers in pharmacology

authors： Yuan P,Ma D,Gao X,Wang J,Li R,Liu Z,Wang T,Wang S,Liu J,Liu X

更新日期：2020-08-12 00:00:00

abstract：:The radioresistance of tumors affect the outcome of radiotherapy. Accumulating data suggest that 1α,25(OH)2D3 is a potential anti-oncogenic molecule in various cancers. In the present study, we investigated the radiosensitive effects and underlying mechanisms of 1α,25(OH)2D3in vitro and in vivo. We found that 1α,25(OH...

journal_title：Frontiers in pharmacology

authors： Ji MT,Nie J,Nie XF,Hu WT,Pei HL,Wan JM,Wang AQ,Zhou GM,Zhang ZL,Chang L,Li BY

更新日期：2020-08-07 00:00:00

abstract：:The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no ...

journal_title：Frontiers in pharmacology

authors： Benarba B,Pandiella A

更新日期：2020-08-07 00:00:00

abstract：Background:As the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored. Methods:We used cell proliferation assay, scratch and transwell experiments, and cell cycle ...

journal_title：Frontiers in pharmacology

authors： Zhang W,Liu C,Li J,Liu R,Zhuang J,Feng F,Yao Y,Sun C

更新日期：2020-08-07 00:00:00

abstract：:The Kinin B2 receptor (B2R) is classically involved in vasodilation and inflammatory responses. However, through the observation of hypoglycemic effects of Angiotensin-I-Converting Enzyme (ACE) inhibitors, this protein has been related to metabolic glucose modulation in physiological and pathophysiological contexts. A...

journal_title：Frontiers in pharmacology

authors： Gregnani MF,Hungaro TG,Martins-Silva L,Bader M,Araujo RC

更新日期：2020-08-04 00:00:00

abstract：:The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challe...

journal_title：Frontiers in pharmacology

authors： Choo WT,Teoh ML,Phang SM,Convey P,Yap WH,Goh BH,Beardall J

更新日期：2020-07-31 00:00:00

abstract：:Successful recovery from hepatectomy is partially contingent upon the rate of residual liver regeneration. The traditional Chinese medicines known as Periplaneta americana extracts (PAEs) positively influence wound healing by promoting tissue repair. However, the effect of PAEs on liver regeneration is unknown. We use...

journal_title：Frontiers in pharmacology

authors： Zou Y,Zhang M,Zeng D,Ruan Y,Shen L,Mu Z,Zou J,Xie C,Yang Z,Qian Z,Xu R,Li S,Kang Q,Zou H,Zhao S,Liu L,Wang K,Wang X,Zhang X

更新日期：2020-07-31 00:00:00

abstract：:Autophagy is an evolutionary conserved physiological process with a fundamental role during development, differentiation, and survival of eukaryotic cells. On the other hand, autophagy dysregulation is observed in many pathological conditions, including cancer. In particular, tumor growth and progression are accompani...

journal_title：Frontiers in pharmacology

authors： Sharma P,Dando I,Strippoli R,Kumar S,Somoza A,Cordani M,Tafani M

更新日期：2020-07-24 00:00:00

abstract：:Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern heal...

journal_title：Frontiers in pharmacology

authors： Marshall ML,Wagstaff KM

更新日期：2020-07-24 00:00:00

abstract：:Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic tools, experimental molecules to validate postulated therapeutic t...

journal_title：Frontiers in pharmacology

authors： Bordon KCF,Cologna CT,Fornari-Baldo EC,Pinheiro-Júnior EL,Cerni FA,Amorim FG,Anjolette FAP,Cordeiro FA,Wiezel GA,Cardoso IA,Ferreira IG,de Oliveira IS,Boldrini-França J,Pucca MB,Baldo MA,Arantes EC

更新日期：2020-07-24 00:00:00

abstract：:Aging leads to changes in nearly all pharmacokinetic phases. Koumine (KM), an alkaloid derived from Gelsemium elegans Benth., is effective against age-associated chronic diseases, but its dose proportionality following oral administration in aged individuals remains unknown. Herein, we established and validated a simp...

journal_title：Frontiers in pharmacology

authors： Ye LX,Xu Y,Zhang SH,Cao DX,Chen LF,Su YP,Huang HH,Yu CX

更新日期：2020-07-21 00:00:00

abstract：:Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII plus tetrandrine (Tetra), a Ch...

journal_title：Frontiers in pharmacology

authors： Yu B,Yuan B,Li J,Kiyomi A,Kikuchi H,Hayashi H,Hu X,Okazaki M,Sugiura M,Hirano T,Fan Y,Pei X,Takagi N

更新日期：2020-07-17 00:00:00

abstract：:Pregnant women appear to be more susceptible to infectious diseases than women in reproductive age. According to the California Department of Public Health pregnant women were 9.6-folds more likely to be hospitalized during the 2009 influenza outbreak when compared to non-pregnant women in reproductive age. In contras...

journal_title：Frontiers in pharmacology

authors： Acosta-Elias J,Espinosa-Tanguma R

更新日期：2020-07-16 00:00:00

abstract：:Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

journal_title：Frontiers in pharmacology

authors： Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

更新日期：2020-07-14 00:00:00

abstract：:Bangpungtongsung-san (BTS) is a traditional Korean medicine consisting of 18 herbs, some which have antidepressant effects. Here, we used an animal model of reserpine-induced depression and lipopolysaccharide (LPS)-stimulated BV2 microglia to assess the antidepressant and anti-neuroinflammatory effects of BTS. Aside f...

journal_title：Frontiers in pharmacology

authors： Park BK,Kim NS,Kim YR,Yang C,Jung IC,Jang IS,Seo CS,Choi JJ,Lee MY

更新日期：2020-07-10 00:00:00

abstract：:Excessive cerebral inflammation plays a key role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Berberine, an isoquinoline alkaloid isolated from Chinese herb Coptis chinensis, possesses anti-inflammatory, and neuroprotective effects. Here we evaluated the beneficial effects of berberine against SAH-...

journal_title：Frontiers in pharmacology

authors： Zhang XH,Peng L,Zhang J,Dong YP,Wang CJ,Liu C,Xia DY,Zhang XS

更新日期：2020-07-10 00:00:00

abstract：:Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, ...

journal_title：Frontiers in pharmacology

authors： Belo RF,Martins MLF,Shvachiy L,Costa-Coelho T,de Almeida-Borlido C,Fonseca-Gomes J,Neves V,Vicente Miranda H,Outeiro TF,Coelho JE,Xapelli S,Valente CA,Heras M,Bardaji E,Castanho MARB,Diógenes MJ,Sebastião AM

更新日期：2020-07-09 00:00:00

abstract：:Chijabyukpi-tang (CBT) is an oriental herbal formula consisting of three herbs (Gardeniae Fructus (Gardenia jasminoides J.Ellis.), Phellodendri Cortex (Phellodendron amurense Rupr.), Glycyrrhizae Radix (Glycyrrhiza uralensis Fisch. ex DC.) at the ratio of 2: 2: 1. CBT has traditionally been used to treat eczema with i...

journal_title：Frontiers in pharmacology

authors： Lee JH,Lim JY,Jo EH,Noh HM,Park S,Park MC,Kim DK

更新日期：2020-07-07 00:00:00

abstract：:The pathophysiology of inflammation and oxidative stress generated during different types of cancers and anticancer treatments is well documented. Traditionally, grape pomace is used for animal feed, organic fertilizers, ethanol production or is disposed as waste. Because grape pomace is a rich source of antioxidant c...

journal_title：Frontiers in pharmacology

authors： Balea ŞS,Pârvu AE,Pârvu M,Vlase L,Dehelean CA,Pop TI

更新日期：2020-07-03 00:00:00

abstract：:Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from 10% to over 30%, thus causing a...

journal_title：Frontiers in pharmacology

authors： Chang CJ,Chen CB,Hung SI,Ji C,Chung WH

更新日期：2020-07-02 00:00:00

abstract：:Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. One of the main irinotecan ...

journal_title：Frontiers in pharmacology

authors： Riera P,Artigas-Baleri A,Salazar J,Sebio A,Virgili AC,Arranz MJ,Páez D

更新日期：2020-06-30 00:00:00

abstract：:B lymphocytes play a critical role in humoral immunity. Abnormal B cell development and function cause a variety of hematological malignancies such as myeloma, B cell lymphoma, and leukemia. Histone deacetylase 6 (HDAC6) inhibitors alone or in combination with other drugs have shown efficacy in several hematological m...

journal_title：Frontiers in pharmacology

authors： Yang J,Li D,Zhou J

更新日期：2020-06-26 00:00:00

abstract：:It is known that calcitonin gene-related peptide (CGRP) plays a key role in pain modulation in the brain. There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. The present study explored the role and mechanisms of CGRP and CGRP recepto...

journal_title：Frontiers in pharmacology

authors： Hou KS,Wang LL,Wang HB,Fu FH,Yu LC

更新日期：2020-06-26 00:00:00

abstract：:Accumulating evidence suggests that Astragaloside IV (AS-IV) improves cardiac function and protects the cardiovascular system. However, the molecular targets involved remain ambiguous. In this work, we report research suggesting that AS-IV can antagonize arrhythmias and reduce the cardiac damage induced by aconitine i...

journal_title：Frontiers in pharmacology

authors： Wang M,Shi Y,Yao L,Li Q,Wang Y,Li J,Fu D

更新日期：2020-06-24 00:00:00

abstract：:Biopeptides derived from marine species have garnered significant research interest owing to their anti-inflammatory, antibacterial, and anticancer activities. In our previous study, Hydrostatin-SN1, a bioactive peptide extracted from the Hydrophis cyanocinctus venom gland T7 phage display library, demonstrated anti-i...

journal_title：Frontiers in pharmacology

authors： Zhang C,Guo S,Wang J,Li A,Sun K,Qiu L,Li J,Wang S,Ma X,Lu Y

更新日期：2020-06-19 00:00:00

abstract：Objective:The study aimed to conduct clinical and economic evaluation of salvianolate injection for patients with coronary heart disease (CHD) in comparison to Danhong injection and alprostadil injection. Method:This was a retrospective study using National Health Insurance Data about inpatients diagnosed with CHD in ...

journal_title：Frontiers in pharmacology

authors： Yang L,Chen X,Oi Lam Ung C,Zhu H,Hu H,Han S

更新日期：2020-06-18 00:00:00

abstract：Background:The importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although natural food contains much more potassium than sodium. The benef...

journal_title：Frontiers in pharmacology

authors： Vio CP,Gallardo P,Cespedes C,Salas D,Diaz-Elizondo J,Mendez N

更新日期：2020-06-18 00:00:00

abstract：:Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced by these bacteria (SEB) acts as a superantigen thereby activating a large proportion of T cells leading to cytokine storm and severe lung injury. Δ9Tetrahydro...

journal_title：Frontiers in pharmacology

authors： Mohammed A,Alghetaa H,Sultan M,Singh NP,Nagarkatti P,Nagarkatti M

更新日期：2020-06-16 00:00:00